![]() ![]() These IDLs return to the liver, which removes about half of them from circulation. Having lost some of its mass, the VLDL particle is now a smaller, less-buoyant molecule called an Intermediate Density Lipoprotein (IDL). The VLDL then deposits its triglycerides into the cell, which can store them or use them for immediate energy. The VLDL is then sent out into your bloodstream, where it circulates until it encounters a cell with an open receptor (typically a smooth muscle cell or fat cell). This molecule is “low-density” in the sense that it floats in blood-it is buoyant. VLDLs are formed when your liver bundles cholesterol along with triglycerides (another fatty substance that stores energy) into a large, protein-wrapped molecule. At the beginning of this chain is the Very Low-Density Lipoprotein (VLDL) molecule. There are many different types of lipoprotein particles that sequentially change into each other as triglycerides are offloaded. The solution is a particle called a lipoprotein-a molecule that encases cholesterol in a hydrophilic shell so that it can travel through the blood in small, discrete parcels. It does not disperse easily in the blood but instead clumps together like oil in water. But this step presents the body with a challenge: Cholesterol is hydrophobic. These organs then export cholesterol to other cells and tissues via the bloodstream. ![]() Every cell can make its own cholesterol, but it’s produced in the largest quantities by the intestines (which absorb and repackage some cholesterol from dietary sources) and the liver. It’s used by cells as a structural material (to build cell membranes and insulate nerve cells) and as a building block for important hormones (e.g. Cholesterol is a waxy substance, a type of fat (lipid) that’s essential for human life. To understand how ApoB predicts cardiovascular risk, we first need to step back and understand cholesterol. But ApoB testing provides important information that these other tests may miss. Many clinicians still rely on traditional cholesterol tests to gauge heart health risk, including LDL cholesterol and triglyceride measurements. For instance, some authors (and doctors) cite the test’s added costs as an obstacle others point out that ApoB testing is very inexpensive. Testing for this protein helps doctors quantify the number of potentially dangerous cholesterol-carrying particles in your body, thus giving insight into your risk of heart disease.ĪpoB is one of several tests used to measure cholesterol levels, and its adoption by medical professionals has been slow (though Europe is slightly ahead). ApoB is a protein that helps carry cholesterol and other important compounds through your bloodstream to the tissues that need them. HealthTab calculates eGFR using the 2009 CKD-EPI creatinine equation as recently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group.The ApoB test measures your body’s level of Apolipoprotein B-100 (also simply known as ApoB).Values below the lower limit of these ranges are still interpreted as ‘Low Risk’ by the HealthTab system because they are usually not of concern from a medical standpoint.National Kidney Disease Education Program.Abaxis – Piccolo® Comprehensive Metabolic Reagent Disc.Abaxis – Piccolo® Lipid Panel Plus Reagent Disc. ![]()
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