We extended this concept of molecular mimicry to dairy proteins as possible etiological factors in the immunopathogenesis of MS by providing evidence of antibody cross-reactivity between another milk protein, casein, and myelin-associated glycoprotein (MAG) ( 17).ĭespite these findings, among others, that highlight the negative effect of dairy intake on the aggravation of MS symptoms ( 6, 7, 18), milk and milk products have been an integral part of human diet for centuries. previously reported sequence homologies between myelin oligodendrocyte glycoprotein (MOG) and butyrophilin (BTN), a milk fat globule membrane protein ( 15). Furthermore, a significant epidemiological association between consumption of bovine milk and milk products and the prevalence of MS has been established by other researchers ( 12– 14).Ī mechanistic link between the potential exacerbation of autoimmune responses in MS patients and the consumption of milk has been suggested by our group and others ( 15– 17). In particular, several studies have comprehensively elucidated how nutrition can act as a possible co-factor influencing the inflammatory cascade in MS patients either directly, by effecting various cellular elements ( 7) or indirectly, by interacting with the gut microbiota ( 8).įor example, the beneficial effect of a diet comprised of fish ( 9), short chain fatty acids ( 10), fruits and vegetables ( 11) on reducing the severity of disease progression in either MS or experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS, has been suggested by different reports. Established environmental risk factors for MS include insufficient sun exposure ( 4), infection with Epstein-Barr virus (EBV) ( 5) and dietary intake ( 6). Nevertheless, it is generally accepted that a complex interaction between genetic predisposition and environmental factors results in the disruption of immunological self-tolerance to myelin antigens of the CNS ( 3). Multiple sclerosis (MS) is the most prevalent chronic inflammatory demyelinating disease of the central nervous system (CNS) ( 1). Finally, our correlation data indicate the co-existence of antibodies to individual bovine milk antigens and their corresponding cross-reactive CNS antigens.ĭiscussion: Taken together, we suggest screening of blood from MS patients for antibodies against different types of milk and milk antigens in order to establish a personalized diet regimen. We also show that the reactivity to cow milk in MS patients can be attributed to reactivity against different bovine milk antigens. Results: We demonstrate that MS patients have a significantly higher IgG response to animal-sourced milk, especially cow milk, in comparison to healthy donors. Methods: To this end, we screened 35 patients with MS and 20 healthy controls for their IgG reactivity against an array of animal-sourced milk, plant-based alternatives as well as individual antigens from bovine milk. In this study we set out to identify alternatives to drinking cow milk which might be less detrimental to MS patients who have a genetic predisposition towards developing antibody titers against bovine milk antigens that cross-react with CNS antigens. We and others have previously demonstrated how consumption of bovine milk can aggravate disease severity in MS patients, which can be explained by molecular mimicry between milk antigens and those expressed within the CNS. The pathophysiology of MS is complex and is said to be influenced by multiple environmental determinants, including diet. Introduction: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). 1Institute of Neuroanatomy, Medical Faculty, University of Bonn, Bonn, Germany.If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.Rittika Chunder 1 Thorsten Heider 2 Stefanie Kuerten 1* Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. īrowse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Choose from 1 of 16 MOG antibodies, which have been validated in experiments with 5 publications and 53 images featured in our data gallery.īrowse primary antibodies for WB, Flow, IHC. Find the MOG antibody that fits your needs. These antibodies have been verified by Relative expression to confirm specificity to MOG. Our MOG polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit, Mouse and Goat. These antibodies target MOG in Human, Mouse, Rat samples. Antibodies that detect MOG can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and Flow Cytometry.
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